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Advancing cancer research using bioprinting for tumor-on-a-chip platforms

VIEWS - 2059 (Abstract) 805 (PDF)
Stephanie Knowlton, Ashwini Joshi, Bekir Yenilmez, Ibrahim Tarik Ozbolat, Chee Kai Chua, Ali Khademhosseini, Savas Tasoglu

Abstract


There is an urgent for a novel approach to cancer research with 1.7 million new cases of cancer occurring every year in the United States of America. Tumor models offer promise as a useful platform for cancer research without the need for animal models, but there remains a challenge to fabricate a relevant model which mimics the structure, function and drug response of human tumors. Bioprinting can address this need by fabricating three-dimensional constructs that mimic tumor heterogeneity, vasculature and spheroid structures. Furthermore, bioprinting can be used to fabricate tissue constructs within microfluidic platforms, forming tumor-on-a-chip devices which are ideal for high-throughput testing in a biomimetic microenvironment. Applications of tumors-on-a-chip include facilitating basic research to better understand tumor development, structure and function as well as drug screening to improve the efficiency of cancer drug discovery.

Keywords


bioprinting; cancer; tumor-on-a-chip; microfabrication; microfluidics; drug screening

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DOI: http://dx.doi.org/10.18063/IJB.2016.02.003

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Copyright (c) 2017 Stephanie Knowlton, Ashwini Joshi, Bekir Yenilmez, Ibrahim Tarik Ozbolat, Chee Kai Chua, Ali Khademhosseini, Savas Tasoglu

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