Biodegradation, Antibacterial Performance, and Cytocompatibility of a Novel ZK30-Cu-Mn Biomedical Alloy Produced by Selective Laser Melting

Bin Xie, Ming-Chun Zhao, Rong Xu, Ying-Chao Zhao, Deng-Feng Yin, Chengde Gao, Andrej Atrens

Article ID: 300
Vol 7, Issue 1, 2021, Article identifier:

VIEWS - 156 (Abstract) 23 (PDF)

In Press, Corrected proof, Published online October 30, 2020


An antibacterial biomedical Mg alloy was designed to have a low biodegradation rate. ZK30-0.2Cu-xMn (x = 0, 0.4, 0.8, 1.2, and 1.6 wt.%) was produced by selective laser melting (SLM). Alloying with Mn had a significant influence on the grain size, hardness, and biodegradation rate. Increasing Mg content to 0.8 wt% decreased the biodegradation rate, attributed to the decreased grain size and the relatively protective manganese surface oxide layer. Higher Mn contents increased the biodegradation rate attributed to the presence of the Mn-rich particles. ZK30-0.2Cu-0.8Mn exhibited the lowest biodegradation rate, strong antibacterial performance and good cytocompatibility.


Magnesium alloy; Selective laser melting; Biodegradation; Antibacterial activity; Grain refinement

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Johnston S, Shi Z, Venezuela J, et al., 2019, Investigating Mg Bio-corrosion In Vitro: Lessons Learned and Recommendations. JOM, 71(4):1406–13.

Zheng Z, Zhao MC, Tan L, et al., 2020, Corrosion Behavior of a Self-Sealing Coating Containing CeO2 Particles on Pure Mg Produced by Micro-Arc Oxidation. Surf Coat Technol, 386:125456.

Lopes DR, Silva CL, Soares RB, et al., 2019, Cytotoxicity and Corrosion Behavior of Magnesium and Magnesium Alloys in Hank’s Solution after Processing by High-Pressure Torsion. Adv Eng Mater, 21(8):1900391.

Rua JM, Zuleta AA, Ramirez J, et al., 2019, Micro-Arc Oxidation Coating on Porous Magnesium foam and its Potential Biomedical Applications. Surf Coat Technol, 360:213–21.

Yan X, Zhao M, Yang Y, et al., 2019, Improvement of Biodegradable and Antibacterial Properties by Solution Treatment and Micro-Arc Oxidation (MAO) of a Magnesium Alloy with a Trace of Copper. Corros Sci, 156:125–38.

Liu C, Fu X, Pan H, et al., 2016, Biodegradable Mg-Cu Alloys with Enhanced Osteogenesis, Angiogenesis, and Long-Lasting Antibacterial Effects. Sci Rep, 6:27374.

Yan X, Wan P, Tan L, et al., 2018, Influence of Hybrid Extrusion and Solution Treatment on the Microstructure and Degradation Behavior of Mg-0.1Cu Alloy. Mater Sci Eng B, 229:105–17.

Gu X, Zheng Y, Cheng Y, et al., 2009, In Vitro Corrosion and Biocompatibility of Binary Magnesium Alloys. Biomaterials, 30:484–98.

Ha HY, Kim HJ, Baek SM, et al., 2015, Improved Corrosion Resistance of Extruded Mg-8Sn-1Zn-1Al Alloy by Microalloying with Mn. Scr Mater, 109:38–43.

Yang Y, Wu P, Wang Q, et al., 2016, The Enhancement of Mg Corrosion Resistance by Alloying Mn and Laser-Melting. Materials, 9:216.

Leach RM, Muenster AM, Wien EM, 1969, Studies on the Role of Manganese in Bone Formation: II. Effect upon Chondroitin Sulfate Synthesis in Chick Epiphyseal Cartilage. Arch Biochem Biophys, 133(1):22–8.

Liu Y, Koltick D, Byrne P, et al., 2013, Development of a Transportable Neutron Activation Analysis System to Quantify Manganese in Bone In Vivo: Feasibility and Methodology. Physiol Meas, 34(12):1593.

Li WX, 2005, Magnesium and its Alloys. Central South University Press, Changsha.

Yu WH, Sing SL, Chua CK, et al., 2019, Particle-Reinforced Metal Matrix Nanocomposites Fabricated by Selective Laser Melting: A State of the Art Review. Prog Mater Sci, 104:330–79.

Li X, Tan Y, Willy H, et al., 2019, Heterogeneously Tempered Martensitic High Strength Steel by Selective Laser Melting and its Micro-Lattice: Processing, Microstructure, Superior Performance and Mechanisms. Mater Des, 178:107881.

Zhao Y, Tang Y, Zhao M, et al., 2019, Graphene Oxide Reinforced Iron Matrix Composite with Enhanced Biodegradation Rate Prepared by Selective Laser Melting. Adv Eng Mater, 21(8):1900314.

Gao C, Yao M, Li S, et al., 2019, Highly Biodegradable and Bioactive Fe-Pd-Bredigite Biocomposites Prepared by Selective Laser Melting. J Adv Res, 20:91–104.

Sing SL, Huang S, Yeong WY, 2020, Effect of Solution Heat Treatment on Microstructure and Mechanical Properties of Laser Powder Bed Fusion Produced Cobalt-28Chromium-6Molybdenum. Mater Sci Eng A, 769:138511.

Tan JH, Sing SL, Yeong WY, 2020, Microstructure Modelling for Metallic Additive Manufacturing: A Review. Virtual Phys Prototyp, 15(1):87–105.

Li X, Tan Y, Wang P, et al., 2020, Metallic Microlattice and Epoxy Interpenetrating Phase Composites: Experimental and Simulation Studies on Superior Mechanical Properties and their Mechanisms. Compos Part A Appl Sci Manuf, 135:105934.

Nie XJ, Chen Z, Qi Y, et al., 2020, Effect of Defocusing Distance on Laser Powder Bed Fusion of High Strength Al-Cu-Mg-Mn Alloy. Virtual Phys Prototyp, 15(3):325–39.

Huang S, Sing SL, Looze G, et al., 2020, Laser Powder Bed Fusion of Titanium-Tantalum Alloys: Compositions and Designs for Biomedical Applications. J Mech Behav Biomed Mater, 108:103775.

Xu R, Zhao M, Zhao Y, et al., 2019, Improved Biodegradation Resistance by Grain Refinement of Novel Antibacterial ZK30-Cu Alloys Produced Via Selective Laser Melting. Mater Lett, 237:253–7.

Zhao YC, Tang Y, Zhao MC, et al., 2020, Study on Fe-xGO Composites Prepared by Selective Laser Melting: Microstructure, Hardness, Biodegradation and Cytocompatibility. JOM, 72:1163–74.

Zhao Y, Zhao M, Xu R, et al., 2019, Formation and Characteristic Corrosion Behavior of Alternately Lamellar Arranged α and β in As-Cast AZ91 Mg Alloy. J Alloys Compd, 770:549–58.

Zhao MC, Liu M, Song GL, et al., 2008, Influence of the β-Phase Morphology on the Corrosion of the Mg Alloy AZ91. Corros Sci, 50:1939–53.

Li Z, Chen M, Li W, et al., 2017, The Synergistic Effect of Trace Sr and Zr on the Microstructure and Properties of a Biodegradable Mg-Zn-Zr-Sr Alloy. J Alloys Compd, 702:290–302.

Zhang X, Hua L, Liu Y, 2012, FE simulation and Experimental Investigation of ZK60 Magnesium Alloy with Different Radial Diameters Processed by Equal Channel Angular Pressing. Mater Sci Eng A, 535:153–63.

Zhao MC, Schmutz P, Brunner S, et al., 2009, An Exploratory Study of the Corrosion of Mg Alloys During Interrupted Salt Spray Testing. Corros Sci, 51(6):1277–92.

Tao JX, Zhao M, Zhao Y, et al., 2020, Influence of Graphene Oxide (GO) on Microstructure and Biodegradation of ZK30-xGO Composites Prepared by Selective Laser Melting. J Magnes Alloys, 8(3):952–62.

Zhao MC, Zhao YC, Yin DF, et al., 2019, Biodegradation Behavior of Coated As-Extruded Mg-Sr Alloy in Simulated Body Fluid. Acta Metall Sin (Engl Lett), 32:1195–206.

Atrens AD, Gentle I, Atrens A, 2015, Possible Dissolution Pathways Participating in the Mg Corrosion Reaction. Corros Sci, 92:173–81.

Song GL, Atrens A, 1999, Corrosion Mechanisms of Magnesium Alloys. Adv Eng Mater, 1:11–33.<11::aidadem11>;2-n

Esmaily M, Svensson JE, Fajardo S, et al., 2017, Fundamentals and Advances in Magnesium Alloy Corrosion. Prog Mater Sci, 89:92–193.

Zhang W, Tan LL, Li DR, et al., 2019, Effect of Grain Refinement and Crystallographic Texture Produced by Friction Stir Processing on the Biodegradation Behavior of a Mg-Nd-Zn Alloy. J Mater Sci Technol, 35(5):777–83.

Kirkland NT, Waterman J, Birbilis N, et al., 2012, Buffer-Regulated Bio-corrosion of Pure Magnesium. J Mater Sci Mater Med, 23(2):283–91.

Nama ND, Mathesh M, Forsyth M, et al., 2012, Effect of Manganese Additions on the Corrosion Behavior of an Extruded Mg-5Al Based Alloy. J Alloys Compd, 542:199–206.

Metalnikov P, Ben-Hamua G, Templeman Y, et al., 2018, The Relation between Mn Additions, Microstructure and Corrosion Behavior of New Wrought Mg-5Al Alloys. Mater Charact, 145:101–15.

Baril G, Pebere N, 2001, The Corrosion of Pure Magnesium in Aerated and Deaerated Sodium Sulphate Solutions. Corros Sci, 43(3):471–84.



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