Advancing cancer research using bioprinting for tumor-on-a-chip platforms

Stephanie Knowlton, Ashwini Joshi, Bekir Yenilmez, Ibrahim Tarik Ozbolat, Chee Kai Chua, Ali Khademhosseini, Savas Tasoglu

Article ID: 77
Vol 2, Issue 2, 2016, Article identifier:3-8

VIEWS - 3512 (Abstract) 1146 (PDF)


There is an urgent for a novel approach to cancer research with 1.7 million new cases of cancer occurring every year in the United States of America. Tumor models offer promise as a useful platform for cancer research without the need for animal models, but there remains a challenge to fabricate a relevant model which mimics the structure, function and drug response of human tumors. Bioprinting can address this need by fabricating three-dimensional constructs that mimic tumor heterogeneity, vasculature and spheroid structures. Furthermore, bioprinting can be used to fabricate tissue constructs within microfluidic platforms, forming tumor-on-a-chip devices which are ideal for high-throughput testing in a biomimetic microenvironment. Applications of tumors-on-a-chip include facilitating basic research to better understand tumor development, structure and function as well as drug screening to improve the efficiency of cancer drug discovery.


bioprinting; cancer; tumor-on-a-chip; microfabrication; microfluidics; drug screening

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