A Study on Dual-Response Composite Hydrogels Based on Oriented Nanocellulose

Lina Dong, Mujiao Liang, Zhongwei Guo, Anyang Wang, Gangpei Cai, Tianying Yuan, Shengli Mi, Wei Sun

Article ID: 578
Vol 8, Issue 3, 2022, Article identifier:578

VIEWS - 314 (Abstract) 120 (PDF) 22 (Supp.File)

Abstract


In nature, many biological tissues are composed of oriented structures, which endow tissues with special properties and functions. Although traditional hydrogels can achieve a high level of biomimetic composition, the orderly arrangement of internal structures remains a challenge. Therefore, it is of great significance to synthesize hydrogels with oriented structures easily and quickly. In this study, we first proposed and demonstrated a fabrication process for producing a well-ordered and dual-responsive cellulose nanofibers + hyaluronic acid methacrylate (CN+HAMA) hydrogels through an extrusion-based three-dimensional (3D) printing process. CN in the CN+HAMA hydrogels are directionally aligned after extrusion due to shear stress. In addition, the synthesized hydrogels exhibited responsive behaviors to both temperature and ultraviolet light. Since the temperature-responsiveness is reversible, the hydrogels can transit between the gelation and solution states while retaining their original qualities. Furthermore, the developed well-oriented CN+HAMA hydrogels induced directional cell growth, paving the way for potential applications in ordered biological soft-tissue repair.


Keywords


Nanocellulose hydrogel; Directional arrangement; Thermal response; Ultraviolet response; 3D printing


Included Database


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DOI: http://dx.doi.org/10.18063/ijb.v8i3.578

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