The Role of 3D-Printed Phantoms and Devices for Organ-specified Appliances in Urology
Vol 7, Issue 2, 2021, Article identifier:333
VIEWS - 1578 (Abstract) 201 (PDF)
Abstract
Urology is one of the fields that are always at the frontline of bringing scientific advancements into clinical practice, including 3D printing (3DP). This study aims to discuss and presents the current role of 3D-printed phantoms and devices for organ-specified applications in urology. The discussion started with a literature search regarding the two mentioned
topics within PubMed, Embase, Scopus, and EBSCOhost databases. 3D-printed urological organ phantoms are reported for providing residents new insight regarding anatomical characteristics of organs, either normal or diseased, in a tangible manner. Furthermore, 3D-printed organ phantoms also helped urologists to prepare a pre-surgical planning strategy with detailed anatomical models of the diseased organs. In some centers, 3DP technology also contributed to developing specified devices
for disease management. To date, urologists have been benefitted by 3D-printed phantoms and devices in the education and disease management of organs of in the genitourinary system, including kidney, bladder, prostate, ureter, urethra, penis, and adrenal. It is safe to say that 3DP technology can bring remarkable changes to daily urological practices.
Keywords
Full Text:
Download PDFReferences
Kamal M, Rizza G. Design for metal additive manufacturing for aerospace applications. In: Additive Manufacturing for the Aerospace Industry. Amsterdam, Netherlands: Elsevier; 2019. p. 67-86. https://doi.org/10.1016/b978-0-12-814062-8.00005-4
Leal R, Barreiros FM, Alves L, et al., 2017, Additive Manufacturing Tooling for the Automotive Industry. Int J Adv Manuf Technol, 92:1671–6. https://doi.org/10.1007/s00170-017-0239-8
Roopavath UK, Kalaskar DM, 2017, 1-Introduction to 3D Printing in Medicine. In: Kalaskar DM, editor. 3D Printing in Medicine, Woodhead Publishing, United Kingdom, pp. 1–20. https://doi.org/10.1016/b978-0-08-100717-4.00001-6
O’Brien KW, Xu PA, Levine DJ, et al., 2018, Elastomeric Passive Transmission for Autonomous Force-Velocity Adaptation Applied to 3D-Printed Prosthetics. Sci Robot.,3:eaau5543. https://doi.org/10.1126/scirobotics.aau5543
Ho CM, Ng SH, Yoon YJ, 2015, A Review on 3D Printed Bio-Implants. Int J Precis Eng Manuf, 16:1035–46.
Whulanza Y, Hidayaturrahmi P, Kurniawati T, et al., 2017, Realization and Testing of Multi-Material 3D Printer for Bone Scaffold Fabrication, Depok City, Indonesia, p. 040001. https://doi.org/10.1063/1.4976786
Abuzairi T, Sumantri NI, Irfan A, et al., 2021, Infrared Thermometer on the Wall (iThermowall): An Open Source and 3-D Print Infrared Thermometer for Fever Screening. HardwareX, 9:e00168. https://doi.org/10.1016/j.ohx.2020.e00168
Norman J, Madurawe RD, Moore CM, et al., 2017, A New Chapter in Pharmaceutical Manufacturing: 3D-Printed Drug Products. Adv Drug Deliv Rev, 108:39–50. https://doi.org/10.1016/j.addr.2016.03.001
Noorani R, 2017, 3D Printing: Technology, Applications, and Selection. CRC Press, United States.
Ng WL, Chua CK, and Shen YF, 2019, Print Me An Organ! Why We Are Not There Yet. Prog Polym Sci, 97:101145. https://doi.org/10.1016/j.progpolymsci.2019.101145
Jordan JM, 2019, 3D Printing. MIT Press, United States.
Pugliese L, Marconi S, Negrello E, et al., 2018, The Clinical use of 3D Printing in Surgery. Updates Surg, 70:381–8. https://doi.org/10.1007/s13304-018-0586-5
Kim GB, Lee S, Kim H, et al., 2016, Three-Dimensional Printing: Basic Principles and Applications in Medicine and Radiology. Korean J Radiol, 17:182–97.
Zheng Y, Yu D, Zhao J, et al., 2016, 3D Printout Models vs. 3D-Rendered Images: Which Is Better for Preoperative Planning? J Surg Educ, 73:518–23. https://doi.org/10.1016/j.jsurg.2016.01.003
Shilo D, Emodi O, Blanc O, et al., 2018, Printing the Future-Updates in 3D Printing for Surgical Applications. Rambam Maimonides Med J, 9:e0020. https://doi.org/10.5041/rmmj.10343
Smith B, Dasgupta P, 2020, 3D printing Technology and Its Role in Urological Training. World J Urol, 38:2385–91. https://doi.org/10.1007/s00345-019-02995-1
Chen MY, Skewes J, Desselle M, et al., 2020, Current Applications of Three-Dimensional Printing in Urology: 3D Printing in Urology. BJU Int, 125:17–27. https://doi.org/10.1111/bju.14928
Mathews DA, Baird A, Lucky M, 2020, Innovation in Urology: Three Dimensional Printing and Its Clinical Application. Front Surg 2020;7:729. https://doi.org/10.3389/fsurg.2020.00029
Cacciamani GE, Okhunov Z, Meneses AD, et al., 2019, Impact of Three-Dimensional Printing in Urology: State of the Art and Future Perspectives. A Systematic Review by ESUT-YAUWP Group. Eur Urol, 76:209–21. https://doi.org/10.1016/j.eururo.2019.04.044
Sun Z, Liu D, 2018, A Systematic Review of Clinical Value of Three-Dimensional Printing in Renal Disease. Quant Imaging Med Surg, 8:311–25. https://doi.org/10.21037/qims.2018.03.09
Redwood B, Schöffer F, Garret B, 2017, The 3D Printing Handbook: Technologies, Design and Applications. 3D Hubs B.V., Netherlands.
Gebhardt A, Hötter JS, 2016, Additive Manufacturing: 3D Printing for Prototyping and Manufacturing. Carl Hanser Verlag GmbH & Company KG, Germany. https://doi.org/10.3139/9781569905838.bm
Rybicki FJ, Grant GT, 2017, 3D Printing in Medicine: A Practical Guide for Medical Professionals. Springer International Publishing, Germany.
Culmone C, Smit G, Breedveld P, 2019, Additive Manufacturing of Medical Instruments: A State-of-the-Art Review. Addit Manuf, 27:461–73. https://doi.org/10.1016/j.addma.2019.03.015
Nyberg EL, Farris AL, Hung BP, et al., 2017, 3D-Printing Technologies for Craniofacial Rehabilitation, Reconstruction, and Regeneration. Ann Biomed Eng, 45:45–57. https://doi.org/10.1007/s10439-016-1668-5
Li W, Mille LS, Robledo JA, et al., 2020, Recent Advances in Formulating and Processing Biomaterial Inks for Vat Polymerization-Based 3D Printing. Adv Healthc Mater, 9:2000156. https://doi.org/10.1002/adhm.202000156
Ishii T, Ho CK, Nahas H, et al., 2019, Deformable Phantoms of the Prostatic Urinary Tract for Urodynamic Investigations. Med Phys, 46:3034–43. https://doi.org/10.1002/mp.13558
Lowther M, Louth S, Davey A, et al., 2019, Clinical, Industrial, and Research Perspectives on Powder Bed Fusion Additively Manufactured Metal Implants. Addit Manuf, 28:565–84. https://doi.org/10.1016/j.addma.2019.05.033
Putra NE, Mirzaali MJ, Apachitei I, et al., 2020, Multi-Material Additive Manufacturing Technologies for Ti-, Mg-, and Fe-Based Biomaterials for Bone Substitution. Acta Biomater, 109:1–20. https://doi.org/10.1016/j.actbio.2020.03.037
Matsiushevich K, 2019, Quantitative Comparison of Freeware Software for Bone Mesh from DICOM Files. J Biomech, 5. 84:247–51. https://doi.org/10.1016/j.jbiomech.2018.12.031
Laycock SD, Hulse M, Scrase CD, et al., 2015, Towards the Production of Radiotherapy Treatment Shells on 3D Printers using Data Derived from DICOM CT and MRI: Preclinical Feasibility Studies. J Radiother Pract, 14:92–8. https://doi.org/10.1017/s1460396914000326
Ng WL, Chan A, Ong YS, et al., 2020, Deep Learning for Fabrication and Maturation of 3D Bio-Printed Tissues and Organs. Virtual Phys Prototyp, 15:340–58.
Ying X, Guo H, Ma K, et al., 2019, X2CT-GAN: Reconstructing CT From Bi-Planar X-Rays With Generative Adversarial Networks. In: 2019 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR), Long Beach, CA, USA, pp. 10611–20. https://doi.org/10.1109/cvpr.2019.01087
Colaco M, Igel DA, Atala A, 2018, The Potential of 3D Printing in Urological Research and Patient Care. Nat Rev Urol, 15:213–21. https://doi.org/10.1038/nrurol.2018.6
Wake N, Rosenkrantz AB, Huang R, et al., 2019, Patient-Specific 3D Printed and Augmented Reality Kidney and Prostate Cancer Models: Impact on Patient educaTion. 3D Print Med, 5:4. https://doi.org/10.1186/s41205-019-0041-3
Ilie PC, Farquhar L, Calleja R, et al., 2018, P06-The Value of Per-sonalised 3D Printing Model of Kidney Stones for Patients Requiring Surgical Treatment. Eur Urol Suppl, 17:e2011–2. https://doi.org/10.1016/s1569-9056(18)32436-9
Atalay HA, Ülker V, Alkan İ, et al., 2016, Impact of Three-Dimensional Printed Pelvi caliceal System Models on Residnts’ Understanding of Pelvicaliceal System Anatomy Before Percutaneous Nephrolithotripsy Surgery: A Pilot Study. J Endourol, 30:1132–7. https://doi.org/10.1089/end.2016.0307
Lee H, Nguyen NH, Hwang SI, et al., 2018, Personalized 3D Kidney Model Produced by Rapid Prototyping Method and its Usefulness in Clinical Applications. Int Braz J Urol, 44:952–7. https://doi.org/10.1590/s1677-5538.ibju.2018.0162
Tatar İ, Huri E, Selçuk İ, et al., 2019, Review of the Effect of 3D Medical Printing and Virtual Reality on Urology Training with “MedTRain3DModsim” Erasmus+European Union Project. Turk J Med Sci, 49:1257–70. https://doi.org/10.3906/sag-1905-73
Cheung CL, Looi T, Lendvay TS, et al., 2014, Use of 3-Dimensional Printing Technology and Silicone Modeling in Surgical Simulation: Development and Face Validation in Pediatric Laparoscopic Pyeloplasty. J Surg Educ, 71:762–7. https://doi.org/10.1016/j.jsurg.2014.03.001
Ghazi A, Stone J, Park J, et al., 2016, V8-01 Full Procedural Simulation for Transurethral Resection of Bladder Tumors (TURBT) Using 3-D Printing Technology. J Urol, 195:e771. https://doi.org/10.1016/j.juro.2016.02.744
Ghazi A, Campbell T, Melnyk R, et al., 2017, Validation of a Full-Immersion Simulation Platform for Percutaneous Nephrolithotomy Using Three-Dimensional Printing Technology. J Endourol, 31:1314–20. https://doi.org/10.1089/end.2017.0366
Sweet RM, 2017, The CREST Simulation Development Process: Training the Next Generation. J Endourol, 31:S69–75.
Parkhomenko E, Yoon R, Okhunov Z, et al., 2019, Multi-Institutional Evaluation of Producing and Testing a Novel 3D-Printed Laparoscopic Trainer. Urology, 124:297–301. https://doi.org/10.1016/j.urology.2018.06.034
Uwechue R, Gogalniceanu P, Kessaris N, et al., 2018, A Novel 3D-Printed Hybrid Simulation Model for Robotic-Assisted Kidney Transplantation (RAKT). J Robot Surg, 12:541–4. https://doi.org/10.26226/morressier .5a38ffa4d462b8029238b6d9
Golab A, Smektala T, Krolikowski M, et al., 2018, Percutaneous Nephrolithotomy Using an Individual 3-Dimensionally Printed Surgical Guide. Urol Int, 100:485–7. https://doi.org/10.1159/000446291
Canat L, Atalay HA, Değirmentepe RB, et al., 2019, Stone Volume Measuring Methods: Should the CT Based Three-Dimensional-Reconstructed Algorithm be Proposed as the Gold Standard? What did the Three-Dimensional Printed Models Show us? Arch Esp Urol, 72:596–601.
Lupulescu C, Sun Z, 2019, A Systematic Review of the Clinical Value and Applications of Three-Dimensional Printing in Renal Surgery. J Clin Med, 8:990.
Fan G, Meng Y, Zhu S, et al., 2019, Three-Dimensional Printing for Laparoscopic Partial Nephrectomy in Patients with Renal Tumors. J Int Med Res, 47:4324–32. https://doi.org/10.1177/0300060519862058
Michiels C, Jambon E, Bernhard JC, 2019, Measurement of the Accuracy of 3D-Printed Medical Models to Be Used for Robot-Assisted Partial Nephrectomy. AJR Am J Roentgenol, 213:626–31. https://doi.org/10.2214/ajr.18.21048
Mercader C, Vilaseca A, Moreno JL, et al., 2019, Role of the Three-Dimensional Printing Technology Incomplex Laparoscopic Renal Surgery: A Renal Tumor in a Horseshoe Kidney. Int Braz J Urol, 45:1129–35. https://doi.org/10.1590/s1677-5538.ibju.2019.0085
Denizet G, Calame P, Lihoreau T, et al., 2019, 3D Multi-Tissue Printing for Kidney Transplantation. Quant Imaging Med Surg, 9:101–6. https://doi.org/10.21037/qims.2018.10.16
Guo YT, Wang H, Wang JP, et al., Two-Year Follow-up on Laparoscopic Three-Dimensional Printed Extravascular Stent Placement for Posterior Nutcracker Syndrome. Chin Med J (Engl), 131:2895–6.
Wang H, Guo YT, Jiao Y, et al., 2019, A Minimally Invasive Alternative for the Treatment of Nutcracker Syndrome using Individualized Three-Dimensional Printed Extravascular Titanium Stents. Chin Med J (Engl), 132:1454–60. https://doi.org/10.1097/cm9.0000000000000255
Zhang J, Zhang P, Wu L, et al., 2018, Application of an Individualized and Reassemblable 3D Printing Navigation Template for Accurate Puncture During Sacral Neuromodulation. Neurourol Urodyn, 37:2776–81. https://doi.org/10.1002/nau.23769
Hassani FA, Peh WY, Gammad GG, et al., 2017, A 3D Printed Implantable Device for Voiding the Bladder Using Shape Memory Alloy (SMA) Actuators. Adv Sci (Weinh), 4:1700143. https://doi.org/10.1002/advs.201700143
Barsky M, Kelley R, Bhora FY, et al., 2018, Customized Pessary Fabrication Using Three-Dimensional Printing Technology. Obstet Gynecol, 131:493–7. https://doi.org/10.1097/aog.0000000000002461
Serrano-Aroca Á, Vera-Donoso CD, Moreno-Manzano V, 2018, Bioengineering Approaches for Bladder Regeneration. Int J Mol Sci, 19:1796. https://doi.org/10.3390/ijms19061796
Adamowicz J, Kuffel B, Van Breda SV, et al., 2019, Reconstructive Urology and Tissue Engineering: Converging Developmental Paths. J Tissue Eng Regen Med, 13:522–33. https://doi.org/10.1002/term.2812
Bejrananda T, Liawrungrueang W, 2020, Successful Transitional Cell Carcinoma of Bladder Underwent Laparoscopic Radical Cystectomy with Orthotopic Intracorporeal Y Pouch Neobladder Using a 3D Digital Printing Model for Surgical Post OP Pouch Evaluation. Urol Case Rep, 31:101190. https://doi.org/10.1016/j.eucr.2020.101190
Kim MJ, Chi BH, Yoo JJ, et al., 2019, Structure Establishment of Three-Dimensional (3D) Cell Culture Printing Model for Bladder Cancer. PLoS One, 14:e0223689. https://doi.org/10.1371/journal.pone.0223689
Wang Y, Gao X, Yang Q, et al., 2015, Three-Dimensional Printing Technique Assisted Cognitive Fusion in Targeted Prostate Biopsy. Asian J Urol, 2:214–9.
Porpiglia F, Bertolo R, Checcucci E, et al., 2018, Development and Validation of 3D Printed Virtual Models for Robot-Assisted Radical Prostatectomy and Partial Nephrectomy: Urologists’ and Patients’ Perception. World J Urol, 36:201–7. https://doi.org/10.1007/s00345-017-2126-1
Shin T, Ukimura O, Gill IS, 2016, Three-Dimensional Printed Model of Prostate Anatomy and Targeted Biopsy-Proven Index Tumor to Facilitate Nerve-Sparing Prostatectomy. Eur Urol, 69:377–9. https://doi.org/10.1016/j.eururo.2015.09.024
Chandak P, Byrne N, Lynch H, et al., 2018, Three-Dimensional Printing in Robot-Assisted Radical Prostatectomy-An Idea, Development, Exploration, Assessment, Long-Term follow up (IDEAL) Phase 2a study. BJU Int, 122:360–1. https://doi.org/10.1111/bju.14189
Ebbing J, Jäderling F, Collins JW, et al., 2018, Comparison of 3D Printed Prostate Models with Standard Radiological Information to Aid Understanding of the Precise Location of Prostate Cancer: A Construct Validation Study. PLoS One, 13:e0199477. https://doi.org/10.1371/journal.pone.0199477
Del Junco M, Yoon R, Okhunov Z, et al., 2015, Comparison of Flow Characteristics of Novel Three-Dimensional Printed Ureteral Stents Versus Standard Ureteral Stents in a Porcine Model. J Endourol, 29:1065–9. https://doi.org/10.1089/end.2014.0716
Park CJ, Kim HW, Jeong S, et al., 2015, Anti-Reflux Ureteral Stent with Polymeric Flap Valve Using Three-Dimensional Printing: An In Vitro Study. J Endourol, 29:933–8. https://doi.org/10.1089/end.2015.0154
Kuroda S, Kawahara T, Teranishi J, et al., 2019, A Case of Allograft Ureteral Stone Successfully Treated with Antegrade Ureteroscopic Lithotripsy: Use of a 3D-Printed Model to Determine the Ideal Approach. Urolithiasis, 47:467–71. https://doi.org/10.1007/s00240-019-01153-x
Joshi PM, Kulkarni SB, 2020, 3D Printing of Pelvic Fracture Urethral Injuries-Fusion of Technology and Urethroplasty. Turk J Urol, 46:76–9. https://doi.org/10.5152/tud.2019.19165
Zhang K, Fu Q, Yoo J, et al., 2017, 3D Bio-Printing of Urethra with PCL/PLCL Blend and Dual Autologous Cells in Fibrin Hydrogel: An In Vitro Evaluation of Biomimetic Mechanical Property and Cell Growth Environment. Acta Biomater, 50:154–64. https://doi.org/10.1016/j.actbio.2016.12.008
D’Alimonte L, Ravi A, Helou J, et al., 2019, Optimized Penile Surface Mold Brachytherapy using Latest Stereolithography Techniques: A Single-Institution Experience. Brachytherapy, 18:348–52. https://doi.org/10.1016/j.brachy.2019.01.002
Yu HS, Park J, Lee HS, et al., 2018, Feasibility of Polycaprolactone Scaffolds Fabricated by Three-Dimensional Printing for Tissue Engineering of Tunica Albuginea. World J Mens Health, 36:66–72. https://doi.org/10.5534/wjmh.17025
Srougi V, Rocha BA, Tanno FY, et al., 2016, The Use of Three-dimensional Printers for Partial Adrenalectomy: Estimating the Resection Limits. Urology, 90:217–20. https://doi.org/10.1016/j.urology.2015.11.043
Lurie KL, Smith GT, Khan SA, et al., 2014, Three-Dimensional, Distendable Bladder Phantom for Optical Coherence Tomography and White Light Cystoscopy. J Biomed Opt, 19:36009. https://doi.org/10.1117/1.jbo.19.3.036009
Chen MY, Skewes J, Daley R, et al., 2020, Three-Dimensional Printing Versus Conventional Machining in the Creation of a Meatal Urethral Dilator: Development and Mechanical Testing. Biomed Eng Online, 19:55. https://doi.org/10.1186/s12938-020-00799-8
Özgür BC, Ayyıldız A, 2018, 3D Printing in Urology: Is it Really Promising? Turk J Urol, 44:6–9.
Manning TG, O’Brien JS, Christidis D, et al., 2018, Three Dimensional Models in Uro-Oncology: A Future Built with Additive Fabrication. World J Urol, 36:557–63. https://doi.org/10.1007/s00345-018-2201-2
DOI: http://dx.doi.org/10.18063/ijb.v7i2.333
Refbacks
- There are currently no refbacks.
Copyright (c) 2021 Natanael Parningotan Agung, Muhammad Hanif Nadhif, Gampo Alam Irdam, Chaidir Arif Mochtar

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.