A Perspective on 4D Bioprinting

Jia An, Chee Kai Chua, Vladimir Mironov

Article ID: 02003
Vol 2, Issue 1, 2016, Article identifier:3-5

VIEWS - 15225 (Abstract) 3910 (PDF)


3D bioprinting has been invented for more than a decade. A disruptive progress is still lacking for the field to significantly move forward. Recently, the invention of 4D printing technology may point a way and hence the birth of 4D bioprinting. However, 4D bioprinting is not well defined and appear to have a few distinct early forms. In this article, a personal perspective on the early forms of 4D bioprinting is presented and a definition for 4D bioprinting is proposed.


4D printing; bioprinting; additive manufacturing; rapid prototyping; tissue engineering

Full Text:

Download PDF

Included Database


Chua C K and Yeong W Y, 2015, Yeong, Bioprinting: Principles and Applications, World Scientific Publishing Company Incorporated, Singapore.

Tibbits S, 2014, 4D printing: Multi-material shape change. Architectural Design, vol.84(1): 116–121. http://dx.doi.org/10.1002/ad.1710

Dababneh A B and Ozbolat I T, 2014, Bioprinting technology: A current state-of-the-art review. Journal of Manufacturing Science and Engineering, vol.136(6): 061016. http://dx.doi.org/10.1115/1.4028512

Khoo Z X, Teoh E M J, Liu Y, et al. 2015, 3D printing of smart materials: A review on recent progresses in 4D printing. Virtual and Physical Prototyping, vol.10(3): 103–122. http://dx.doi.org/10.1080/17452759.2015.1097054

Wang S, Lee J M and Yeong W Y, 2015, Smart hydrogels for 3D bioprinting. International Journal of Bioprinting, vol.1(1): 3–14. http://dx.doi.org/10.18063/IJB.2015.01.005

Mironov V, 2014, Proceedings of the 1st International Bioprinting Congress, July 24–25, 2014: 4D Bioprinting: Biofabrication of rod-like and tubular tissue engineered constructs using programmable self-folding bioprinted


Morrison R J, Hollister S J, Niedner M F, et al. 2015, Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients. Science Translational Medicine, vol.7(285): 285ra64. http://dx.doi.org/10.1126/scitranslmed.3010825

Guillemot F, 2015, Proceedings of the 2nd International Bioprinting Congress, July 9–10, 2015: 4D bioprinting: A new paradigm for engineering complex tissues.

Kuribayashi-Shigetomi K, Onoe H and Takeuchi S, 2012, Cell origami: Self-folding of three-dimensional cell-laden microstructures driven by cell traction force, PLOS ONE, vol.7(12): e51085. http://dx.doi.org/10.1371/journal.pone.0051085

DOI: http://dx.doi.org/10.18063/IJB.2016.01.003


  • There are currently no refbacks.

Copyright (c) 2017 Jia An, Chee Kai Chua, Vladimir Mironov

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.