Preparation and Characterization of 3D Printed Porous 45S5 Bioglass Bioceramic for Bone Tissue Engineering Application

Authors

  • Zhihong Dong School of Mechanical Engineering, Chengdu University, Chengdu, 610106, China
  • Jiabao Gong School of Mechanical Engineering, Chengdu University, Chengdu, 610106, China
  • Haowei Zhang College of Electronics and Information Engineering, Sichuan University, Chengdu 610065, China
  • Yanting Ni School of Mechanical Engineering, Chengdu University, Chengdu, 610106, China
  • Lijia Cheng Department of Stomatology, The Affiliated Hospital of Chengdu University, Chengdu, 610081, China
  • Qiaoyu Song School of Mechanical Engineering, Chengdu University, Chengdu, 610106, China
  • Lu Tang Department of Stomatology, The Affiliated Hospital of Chengdu University, Chengdu, 610081, China
  • Fei Xing Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, China
  • Ming Liu Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, China
  • Changchun Zhou National Engineering Research Center for Biomaterials and College of Biomedical Engineering, Sichuan University, Chengdu 610064, China

DOI:

https://doi.org/10.18063/ijb.v8i4.613

Keywords:

3D printing, LCD stereolithography, 45S5 Bioglass, Bone tissue engineering

Abstract

Three-dimensional (3D) printing technology provides advanced technical support for designing personalized bone tissue engineering scaffold. In this study, two porous diffusing models, namely, average and layered perforated cylindrical scaffolds, were designed for bone tissue engineering scaffold. The designed models were fabricated by liquid crystal display mask stereolithography printing. Structural design and finite element mechanical analysis were conducted. 45S5 bioglass was selected as the raw material for preparing the printing inks for bone tissue engineering scaffolds. By adjusting the viscosity and temperature of the slurry, the maximum proportion of 45S5 bioglass (40 wt%) was added into the photosensitive resin for preparing 3D printing slurry. Our results indicated that an optimized sintering condition includes the debinding rate (0.5°C/ min), and temperature raising rate (5°C/min) and sintering temperature (1100°C) were proposed to sinter 45S5 bioceramic scaffolds. The amorphous 45S5 bioglass showed good crystallization after sintering, and the scaffold porous structure showed good integrity. Micropores were observed in the struts which interconnected with each other. Moreover, the porosities were tested as 57% and 45% with a uniform pore distribution. The shrinkage rate was about 10% during sintering process due to binder burning and crystallization shrinkage. The compressive strength of the sintered scaffold was 0.71 ± 0.048 MPa and 2.13 ± 0.054 MPa, respectively, which are consistent with the finite element mechanical analysis simulation results. In conclusion, the layered perforated 45S5 bioglass scaffold shows good mechanical properties and porosity, indicating that it could be a promising candidate for bone tissue engineering.

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Published

2022-09-01

Issue

Vol. 8 No. 4 (2022): International Journal of Bioprinting

Section

Research Article

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Copyright (c) 2022 Zhihong Dong, Jiabao Gong, Haowei Zhang, Yanting Ni, Lijia Cheng, Qiaoyu Song, Lu Tang, Fei Xing, Ming Liu, Changchun Zhou

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