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Table of Contents

Special Section: Research and Applications of 3D Printing and Bioprinting for Covid-19




Regular Section

Original Articles

by Linzhi Jing, Jie Sun, Hang Liu, Xiang Wang, Dejian Huang
171 Views, 44 PDF Downloads

Electrohydrodynamic printing (EHDP) is capable of fabricating micro- to nano-scale fibrous scaffolds for three-dimensional (3D) cell cultures and tissue engineering applications. One of the major bottlenecks that limits the widespread EHDP is the lack of biomaterial ink solutions with tunable mechanical, chemical, and biological properties. In this work, we blend plant protein nanoparticles with synthetic polymer poly(ε-caprolactone) (PCL) to develop composite biomaterial inks, such as PCL/gliadin and PCL/zein for EHDP scaffold fabrication. The tensile test results showed that the composite materials with a relatively small amount of plant protein nanoparticles, such as PCL/gliadin-10, PCL/zein-10 can significantly increase both Young’s modulus and yield stress of the fabricated scaffolds. These scaffolds are further evaluated by culturing mouse embryonic fibroblasts (NIH/3T3) cells, and proven to enhance cell adhesion and proliferation, apart from temporary inhibition effects for PCL/gliadin-20 scaffold at the initial growth stage. After these plant protein nanoparticles are gradually released into culture medium, the generated nanoporous structures on the scaffolds are also favorable to cellular attachment, migration, and proliferation. As competent candidates to upregulate cell biological behaviors in 3D microenvironment, such composite scaffolds manifest a great potential in drug screening and 3D in vitro model development.     

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Original Articles

by Bin Xie, Ming-Chun Zhao, Rong Xu, Ying-Chao Zhao, Deng-Feng Yin, Chengde Gao, Andrej Atrens
156 Views, 23 PDF Downloads

An antibacterial biomedical Mg alloy was designed to have a low biodegradation rate. ZK30-0.2Cu-xMn (x = 0, 0.4, 0.8, 1.2, and 1.6 wt.%) was produced by selective laser melting (SLM). Alloying with Mn had a significant influence on the grain size, hardness, and biodegradation rate. Increasing Mg content to 0.8 wt% decreased the biodegradation rate, attributed to the decreased grain size and the relatively protective manganese surface oxide layer. Higher Mn contents increased the biodegradation rate attributed to the presence of the Mn-rich particles. ZK30-0.2Cu-0.8Mn exhibited the lowest biodegradation rate, strong antibacterial performance and good cytocompatibility.

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Original Articles

by Marlon Wesley Machado Cunico
63 Views, 10 PDF Downloads

Dental prosthesis and restoration technologies have been developed in the past years. Despite the advantages of additive manufacturing, computer-aided design, and computer-aided manufacturing technologies are still the dominant type of method for fabricating prostheses. Therefore, the main goal of this study is to assess the feasibility of using indirect fused deposition modeling to fabricate dental prosthesis made of ZrSiO4-glass composites. To achieve this goal, filaments were filled by 90% of ZrSiO4 and 50 μm glass spheres to fabricate prosthesis. Multivariable approach was applied to evaluate the feasibility of the proposed method. Holding temperature, holding time, heating rate, and cooling rate were considered the control factors, while shrinkage, flexural strength, and process feasibility were the study responses. In addition, the flexural strength of materials was found between 25 and 85 MPa, while shrinkage fluctuated between 10 and 25%.

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