Digital biomanufacturing supporting vascularization in 3D bioprinting

VIEWS - 290 (Abstract) 538 (PDF)
William Whitford, James B. Hoying

Abstract


Synergies in bioprinting are appearing from individual researchers focusing on divergent aspects of the technology. Many are now evolving from simple mono-dimensional operations to model-controlled multi-material, interpenetrating networks using multi-modal deposition techniques. Bioinks are being designed to address numerous critical process parameters. Both the cellular constructs and architectural design for the necessary vascular component in digitally biomanufactured tissue constructs is being addressed. Advances are occurring from the topology of the circuits to the source of the of the biological microvessel components. Instruments monitoring and control of these activates are becoming interconnected. More and higher quality data are being collected and analysis is becoming richer. Information management and model generation is now describing a “process network.” This is promising; more efficient use of both locally and imported raw data supporting accelerated strategic as well as tactical decision making. This allows real time optimization of the immediate bioprinting bioprocess based on such high value criteria as instantaneous progress assessment and comparison to previous activities. Finally, operations up- and down-stream of the deposition are being included in a supervisory enterprise control.


Keywords


digital; biomanufacturing; bioprinting; vasculogenesis; microvasculatures; bioinks

Full Text:

PDF

References


Rouse M, 2016, Definition: digital manufacturing, Tech-Target, viewed November 3, 2016,

http://searchmanufacturingerp.Techtarget.Com/definition/digital-manufacturing

Todorovic MH, Datta R, Stevanovic L, et al,. 2016, Proceedings of PCIM Europe 2016; International Exhibition and Conference for Power Electronics, Intelligent Motion, Renewable Energy and Energy Management, May 10–12, 2016: Design and testing of a modular SiC based pow-er block. Nuremberg, Germany. pp. 1–4.

http://ieeexplore.ieee.org/abstract/document/7499578/

Fan H and Scott C, 2015, From chips to CHO cells: IT advances in upstream bioprocessing, BioProcess International, viewed November 11, 2016,

http://www.Bioprocessintl.Com/manufacturing/information-technology/from-chips-to-cho-cells-it-advances-in-upstream-bioprocessing/

National Science Foundation, 2013, NSF workshop report – advanced biomanufacturing, viewed November 5, 2016,

http://www.nsf.gov/eng/cbet/documents/adv_biomanufacturing.pdf

Stackpole B, 2016, 3D printing a key piece of digital manufacturing puzzle, TechTarget, viewed November 13, 2016,

http://searchmanufacturingerp.techtarget.com/feature/3D-printing-a-key-piece-of-digital-manufacturing-puzzle

TSIM® software, n.d., viewed November 12, 2016,

http://www.lifesciences.solutions/tsim-software.html

Jose R R, Rodriguez M J, Dixon T A, et al., 2016, Evolution of bioinks and additive manufacturing technologies for 3D bioprinting. ACS Biomaterials Science and Engi-neering, vol.2(10): 1662–1678.

http://dx.doi.org/10.1021/acsbiomaterials.6b00088

Sundaramurthi D, Rauf S, and Hauser C, 2016, 3D bioprinting technology for regenerative medicine applications. International Journal of Bioprinting, vol.2(2): 9–26.

http://ijb.whioce.com/index.php/int-j-bioprinting/article/view/78

Whitford W G and Hoying J B, 2016, A bioink by any other name: Terms, concepts and constructions related to 3D bioprinting. Future Science OA, vol.2(3): FSO133. http://dx.doi.org/10.4155/fsoa-2016-0044

Jang J, Kim T G, Kim B S, et al., 2016, Tailoring mechanical properties of decellularized extracellular matrix bioink by vitamin B2-induced photo-crosslinking. Acta Biomaterialia, vol.33: 88–95.

https://doi.org/10.1016/j.actbio.2016.01.013

Pati F, Jang J, Ha D H, et al., 2014, Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink. Nature Communications, vol.5: 3935. https://doi.org/10.1038/ncomms4935

Ghosh S, Parker S T, Wang X, et al., 2008, Direct-write assembly of microperiodic silk fibroin scaffolds for tissue engineering applications. Advanced Functional Materials, vol.18(13): 1883–1889.

http://dx.doi.org/10.1002/adfm.200800040

Organovo Holdings Inc., 2016, Science and technology, viewed November 14, 2016,

http://organovo.com/science-technology/

Whitford W G, 2016, Conference of Bioprinting and 3D Printing in the Life Sciences, July 21–22, 2016: Bioinks supporting angiogenic potential in organ printing.

https://selectbiosciences.Com/conferences/agendaabstracts.Aspx?Conf=bio3d&abstractid=11535

Armstrong J P K, Burke M, Carter B M, et al., 2016, 3D bioprinting using a templated porous bioink. Advanced Healthcare Materials, vol.5(14): 1724–1730.

http://dx.doi.org/10.1002/adhm.201600022

Alakpa E V, Jayawarna V, Lampel A, et al., 2016, Tunable supramolecular hydrogels for selection of lineage-guiding metabolites in stem cell cultures. Chem, vol.1(2): 298–319.

https://doi.org/10.1016/j.chempr.2016.07.001

Patel P, 2016, The path to printed body parts — scientists are making steady progress toward 3-D printed tissues and organs. ACS Central Science, vol.2(9): 581–583.

https://doi.org/10.1021/acscentsci.6b00269

Advanced Solutions Inc., n.d., BioAssemblyBot™, viewed November 1, 2016,

http://www.lifesciences.solutions/bioprinters.html#more

Zorlutuna P, Annabi N, Camci-Unal G, et al., 2012, Mi-crofabricated biomaterials for engineering 3D tissues. Advanced Materials, vol.24(14): 1782–1804.

https://doi.org/10.1002/adma.201104631

Vanderburgh J, Sterling J A, Guelcher S A, 2016, 3D printing of tissue engineered constructs for in vitro modeling of disease progression and drug screening. Annals of Biomedical Engineering, 1–16. (In Press).

https://doi.org/10.1007/s10439-016-1640-4

Lokmic Z, Mitchell G M, 2008, Engineering the microcirculation. Tissue Engineering Part B: Reviews, vol. 14(1): 87–103.

https://dx.doi.org/10.1089/teb.2007.0299

LeBlanc A J, Krishnan L, Sullivan C J, et al., 2012, Microvascular repair: post-angiogenesis vascular dynamics. Microcirculation, vol.19(8): 676–695.

https://doi.org/10.1111/j.1549-8719.2012.00207.x

Hoying J B, Utzinger U, Weiss J A, 2014, Formation of microvascular networks: role of stromal interactions directing angiogenic growth. Microcirculation, vol.21(4): 278–289. https://doi.org/10.1111/micc.12115

Muscari C, Giordano E, Bonafè F, et al., 2014, Strategies affording prevascularized cell-based constructs for myocardial tissue engineering. Stem Cells International, vol.2014: 434169. https://doi.org/10.1155/2014/434169

Visconti R P, Kasyanov V, Gentile C, et al., 2010, Towards organ printing: engineering an intra-organ branched vascular tree. Expert Opinion on Biological Therapy, vol.10(3): 409–420.

http://dx.doi.org/10.1517/14712590903563352

Moya M L, Hsu Y H, Lee A P, et al., 2013, In vitro perfused human capillary networks. Tissue Engineering Part C: Methods, vol.19(9): 730–737.

http://dx.doi.org/10.1089/ten.tec.2012.0430.

Carmeliet P, 2005, Angiogenesis in life, disease and medicine. Nature, vol.438(7070): 932–936.

https://dx.doi.org/10.1038/nature04478

Shepherd B R, Chen H Y S, Smith C M, et al., 2004, Rapid perfusion and network remodeling in a microvascular construct after implantation. Arteriosclerosis, Thrombosis and Vascular Biology, vol.24: 898–904.

https://doi.org/10.1161/01.ATV.0000124103.86943.1e

Nunes S S, Maijub J G, Krishnan L, et al., 2013, Generation of a functional liver tissue mimic using adipose stromal vascular fraction cell-derived vasculatures. Scientific Reports, vol.3: 2141.

https://doi.org/10.1038/srep02141

Laib A M, Bartol A, Alajati A, et al., 2009, Spheroid-based human endothelial cell microvessel formation in vivo. Nature Protocols, vol.4: 1202–1215.

https://doi.org/10.1038/nprot.2009.96

Pries A R, Reglin B and Secomb T W, 2005, Remodeling of blood vessels: Responses of diameter and wall thickness to hemodynamic and metabolic stimuli. Hypertension, vol.46: 725-731.

https://doi.org/10.1161/01.HYP.0000184428.16429.be

Lee V K, Lanzi A M, Haygan N, et al., 2014, Generation of multi-scale vascular network system within 3D hydrogel using 3D bio-printing technology. Cellular and Molecular Bioengineering, vol.7(3): 460-472

https://doi.org/10.1007/s12195-014-0340-0

Laschke M W, Kleer S, Schuler S, et al., 2012, Vascularisation of porous scaffolds is improved by incorporation of adipose tissue-derived microvascular fragments. European Cells & Materials, vol.24: 266–277.

https://doi.org/10.22203/eCM.v024a19

Montanez E, Casaroli-Marano R P, Vilaro S, et al., 2002, Comparative study of tube assembly in three-dimensional collagen matrix and on Matrigel coats. Angiogenesis, vol.5(3): 167–172.

https://doi.org/10.1023/A:1023837821062

Hemshekhar M, Thushara R M, Chandranayaka S, et al., 2016, Emerging roles of hyaluronic acid bioscaffolds in tissue engineering and regenerative medicine. International Journal of Biological Macromolecules, vol.86: 917–928.

https://doi.org/10.1016/j.ijbiomac.2016.02.032

Zheng Y, Chen J, Craven M, et al., 2012, In vitro microvessels for the study of angiogenesis and thrombosis. Proceedings of the National Academy of Sciences of the United States of America, vol.109(24): 9342–9347.

https://doi.org/10.1073/pnas.1201240109

Moya M L, Hsu Y H, Lee A P, et al., 2013, In vitro perfused human capillary networks. Tissue Engineering. Part C: Methods, vol.19(9): 730–737.

https://doi.org/10.1089/ten.TEC.2012.0430

Zorlutuna P, Annabi N, Camci-Unal G, et al., 2012, Microfabricated biomaterials for engineering 3D tissues. Advanced Materials, vol.24(14): 1782–1804.

https://doi.org/10.1002/adma.201104631

Jose R R, Rodriguez M J, Dixon T A, et al., 2016, Evolution of bioinks and additive manufacturing technologies for 3D bioprinting. ACS Biomaterials Science & Engineering, vol.2(10): 1662–1678.

https://doi.org/10.1021/acsbiomaterials.6b00088

Vanderburgh J, Sterling J A and Guelcher S A, 2017, 3D printing of tissue engineered constructs for in vitro modeling of disease progression and drug screening. Annals of Biomedical Engineering, vol.45(1): 164–179.

https://doi.org/10.1007/s10439-016-1640-4




DOI: http://dx.doi.org/10.18063/IJB.2017.01.002

Refbacks

  • There are currently no refbacks.


Copyright (c) 2017 William Whitford, James B. Hoying

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Recent Articles | About Journal | For Author | Fees | About Whioce

Copyright © Whioce Publishing Pte Ltd. All Rights Reserved.