Discovering the Latest Scientific Pathways on Tissue Spheroids: Opportunities to Innovate
Vol 7, Issue 1, 2021, Article identifier:331
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Abstract
Tissue spheroids consist of a three-dimensional model of cells which is capable of imitating the complicated composition of healthy and unhealthy human tissue. Due to their unique properties, they can bring innovative solutions to tissue engineering and regenerative medicine, where they can be used as building blocks for the formation of organ and tissue models used in drug experimentation. Considering the rapid transformation of the health industry, it is crucial to assess the research dynamics of this field to support the development of innovative applications. In this research, a scientometric analysis was performed as part of a Competitive Technology Intelligence methodology, to determine the main applications of tissue spheroids. Papers from Scopus and Web of Science published between 2000 and 2019 were organized and analyzed. In total, 868 scientific publications were identified, and four main categories of application were determined. Main subject areas, countries, cities, authors, journals, and institutions were established. In addition, a cluster analysis was performed to determine networks of collaborations between institutions and authors. This article provides insights into the applications of cell aggregates and the research dynamics of this field, which can help in the decision-making process to incorporate emerging and innovative technologies in the health industry.
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Donderwinkel I, Hest JC, Cameron NR, 2017, Bio-inks for 3D Bio-Printing: Recent Advances and Future Prospects. Polym. Chem , 8:4451–71. https://doi.org/10.1039/c7py00826k
Ngo TD, Kashami A, Imbalzano G, et al., 2018, Additive Manufacturing (3D Printing): A Review of Materials, Methods, Applications and Challenges. Compos B Eng, 143:172–96. https://doi.org/10.1016/j.compositesb.2018.02.012
Ashammakhi N, Ahadian S, Xu C, et al., 2019, Bioinks and Bio-Printing Technologies to Make Heterogeneous and Biomimetic Tissue Constructs. Mater Today Bio, 1:100008. https://doi.org/10.1016/j.mtbio.2019.100008
Schwab A, Levato R, D’Este M, et al., 2020, Printability and Shape Fidelity of Bioinks in 3D Bioprinting. Chem Rev, 120:11028–55. https://doi.org/10.1021/acs.chemrev.0c00084
Ng WL, Chua CK, Shen YF, 2019, Print Me An Organ! Why We Are Not There Yet. Prog Polym Sci, 97:101145. https://doi.org/10.1016/j.progpolymsci.2019.101145
Ji S, Guvendiren M, 2017, Recent Advances in Bioink Design for 3D Bio-Printing of Tissues and Organs. Front Bioeng Biotechnol, 5:23. https://doi.org/10.3389/fbioe.2017.00023
Lee JM, Ng WL, Yeong WY, 2019, Resolution and Shape in Bio-Printing: Strategizing Towards Complex Tissue and Organ Printing. Appl Phys Rev, 6:11307. https://doi.org/10.1063/1.5053909
Colosi C, Shin SR, Manoharan V, et al., 2016, Microfluidic Bio-Printing of Heterogeneous 3D Tissue Constructs Using Low-Viscosity Bioink. Adv Mater, 28:677–84. https://doi.org/10.1002/adma.201503310
Hospodiuk M, Dey M, Sosnoski D, et al., 2017, The Bioink: A Comprehensive Review on Bio-Printable Materials. Biotechnol Adv, 35:217–39.
Rezende RA, Pereira FD, Kasyanov V, et at., 2013, Scalable biofabrication of tissue spheroids for organ printing. In: Procedia CIRP. Vol. 5. Amsterdam, Elsevier. pp276–81. https://doi.org/10.1016/j.procir.2013.01.054
Sriphutkiat Y, Kasetsirikul S, Zhou Y, 2018, Formation of Cell Spheroids Using Standing Surface Acoustic Wave (SSAW). Int J Bioprint, 4:130. https://doi.org/10.18063/ijb.v4i1.130
Costa EC, Melo-Diogo DD, Moreira AF, et al., 2017, Spheroids Formation on Non-Adhesive Surfaces by Liquid Overlay Technique: Considerations and Practical Approaches. Biotechnol J, 13:1002. https://doi.org/10.1002/biot.201700417
Gopinathan J, Noh I, 2018, Recent Trends in Bio-Inks for 3D Printing. Biomater Res, 22:11.
Murphy SV, Atala A, 2014, 3D Bio-Printing of Tissues and Organs. Nat Biotechnol, 32:773–85.
Jose RR, Rodriguez MJ, Dixon TA, et al., 2016, Evolution of Bio-Inks and Additive Manufacturing Technologies for 3D Bio-Printing. ACS Biomater Sci Eng, 2:1662-78.
Mehesz AN, Brown J, Hajdu Z, et al., 2011, Scalable Robotic Bio-Fabrication of Tissue Spheroids. Biofabrication, 3:025002. https://doi.org/10.1088/1758-5082/3/2/025002
Peng W, Unutmaz D, Ozbolat IT, 2016, Bio-Printing towards Physiologically Relevant Tissue Models for Pharmaceutics. Trends Biotechnol, 34:722–32. https://doi.org/10.1016/j.tibtech.2016.05.013
Toit AS, 2015, Competitive Intelligence Research: An Investigation of Trends in the Literature. J Intell Stud Bus, 5:14–21.
Rodríguez-Salvador M, Villarreal-Garza D, Álvarez MM, et al., 2019, Analysis of the Knowledge Landscape of Three-Dimensional Bio-Printing in Latin America. Int J Bioprint, 5:240. https://doi.org/10.18063/ijb.v5i2.3.240
Elsevier, 2019, Scopus. Available from: https://www.elsevier.com/solutions/scopus. [Last accessed on 2020 Oct 20].
Clarivate Analytics, 2019, Databases. Available from: https://www.clarivate.com/products/web-of-science/databases. [Last accessed on 2020 Oct 20].
Machino R, Matsumoto K, Taniguchi D, et al., 2019, Replacement of Rat Tracheas by Layered, Trachea-Like, Scaffold-Free Structures of Human Cells Using a Bio-3D Printing System. Adv Healthc Mater, 8:1800983. https://doi.org/10.1002/adhm.201800983
Daly AC, Kelly DJ, 2019, Bio-Fabrication of Spatially Organised Tissues by Directing the Growth of Cellular Spheroids within 3D Printed Polymeric Microchambers. Biomaterials, 197:194–206. https://doi.org/10.1016/j.biomaterials.2018.12.028
Anada T, Pan CC, Stahl AM, et al., 2019, Vascularized Bone-Mimetic Hydrogel Constructs by 3D Bioprinting to Promote Osteogenesis and Angiogenesis. Int J Mol Sci, 20:1096. https://doi.org/10.3390/ijms20051096
Lee C, Abelseth E, de la Vega L, et al., 2019, Bioprinting a Novel Glioblastoma Tumor Model Using a Fibrin-Based Bio-Ink for Drug Screening. Mater Today Chem, 12:78–84. https://doi.org/10.1016/j.mtchem.2018.12.005
DOI: http://dx.doi.org/10.18063/ijb.v7i1.331
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