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Printing amphotericin B on microneedles using matrix-assisted pulsed laser evaporation
Vol 3, Issue 2, 2017, Article identifier:147-157
VIEWS - 6837 (Abstract) 1250 (PDF)
Abstract
Transdermal delivery of amphotericin B, a pharmacological agent with activity against fungi and parasitic protozoa, is a challenge since amphotericin B exhibits poor solubility in aqueous solutions at physiologic pH values. In this study, we have used a laser-based printing approach known as matrix-assisted pulsed laser evaporation to print amphotericin B on the surfaces of polyglycolic acid microneedles that were prepared using a combination of injection molding and drawing lithography. In a modified agar disk diffusion assay, the amphotericin B-loaded microneedles showed concentrationdependent activity against the yeast Candida albicans. The results of this study suggest that matrix-assisted pulsed laser evaporation may be used to print amphotericin B and other drugs that have complex solubility issues on the surfaces of microneedles.
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DOI: http://dx.doi.org/10.18063/IJB.2017.02.004
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Copyright (c) 2017 Roger Sachan, Panupong Jaipan, Jennifer Y. Zhang, Simone Degan, Detlev Erdmann, Jonathan Tedesco, Lyndsi Vanderwal, Shane J. Stafslien, Irina Negut, Anita Visan, Gabriela Dorcioman, Gabriel Socol, Rodica Cristescu, Douglas B. Chrisey, Roger J. Narayan
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